| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Thymidylate synthase |
|---|
| Ligand | BDBM50035015 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_208948 (CHEMBL814567) |
|---|
| Ki | 6000±n/a nM |
|---|
| Citation |  Varney, MD; Palmer, CL; Deal, JG; Webber, S; Welsh, KM; Bartlett, CA; Morse, CA; Smith, WW; Janson, CA Synthesis and biological evaluation of novel 2,6-diaminobenz[cd]indole inhibitors of thymidylate synthase using the protein structure as a guide. J Med Chem38:1892-903 (1995) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Thymidylate synthase |
|---|
| Name: | Thymidylate synthase |
|---|
| Synonyms: | TS | TSase | TYMS | TYSY_HUMAN | Thymidylate synthase (TS) | Thymidylate synthase/GAR transformylase/AICAR transformylase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 35718.07 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 313 |
|---|
| Sequence: | MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
|
|
|
|---|
| BDBM50035015 |
|---|
| n/a |
|---|
| Name | BDBM50035015 |
|---|
| Synonyms: | CHEMBL55884 | N*6*-Methyl-N*6*-pyridin-4-ylmethyl-benzo[cd]indole-2,6-diamine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H16N4 |
|---|
| Mol. Mass. | 288.3464 |
|---|
| SMILES | CN(Cc1ccncc1)c1ccc2N=C(N)c3cccc1c23 |t:14| |
|---|
| Structure | 
|
|---|
Search and Browse
