Reaction Details |
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Target | Integrase |
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Ligand | BDBM49181 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_940681 (CHEMBL2327747) |
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IC50 | >20000±n/a nM |
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Citation | Serrao, E; Debnath, B; Otake, H; Kuang, Y; Christ, F; Debyser, Z; Neamati, N Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction. J Med Chem56:2311-22 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Integrase |
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Name: | Integrase |
Synonyms: | pol |
Type: | PROTEIN |
Mol. Mass.: | 32203.43 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_106649 |
Residue: | 288 |
Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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BDBM49181 |
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n/a |
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Name | BDBM49181 |
Synonyms: | 5-(4-Benzyl-piperazin-1-ylmethyl)-quinolin-8-ol | 5-[(4-benzylpiperazin-1-yl)methyl]quinolin-8-ol | 5-[(4-benzylpiperazino)methyl]quinolin-8-ol | 5-[[4-(phenylmethyl)-1-piperazinyl]methyl]-8-quinolinol | 5-[[4-(phenylmethyl)piperazin-1-yl]methyl]quinolin-8-ol | MLS000075465 | SMR000014637 | cid_651866 |
Type | Small organic molecule |
Emp. Form. | C21H23N3O |
Mol. Mass. | 333.4268 |
SMILES | Oc1ccc(CN2CCN(Cc3ccccc3)CC2)c2cccnc12 |
Structure |
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