Reaction Details |
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Target | Reverse transcriptase |
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Ligand | BDBM50251011 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_969007 (CHEMBL2400596) |
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IC50 | 3200±n/a nM |
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Citation | Masaoka, T; Chung, S; Caboni, P; Rausch, JW; Wilson, JA; Taskent-Sezgin, H; Beutler, JA; Tocco, G; Le Grice, SF Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. J Med Chem56:5436-45 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Reverse transcriptase |
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Name: | Reverse transcriptase |
Synonyms: | n/a |
Type: | Protein |
Mol. Mass.: | 29598.37 |
Organism: | Human immunodeficiency virus 1 |
Description: | Q9WKE8 |
Residue: | 254 |
Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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BDBM50251011 |
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n/a |
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Name | BDBM50251011 |
Synonyms: | CHEMBL2397398 |
Type | Small organic molecule |
Emp. Form. | C17H16N2O2S |
Mol. Mass. | 312.386 |
SMILES | Oc1ccc(cc1)-c1nc2sc3CCCCCc3c2c(=O)[nH]1 |
Structure |
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