| Reaction Details |
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 | Report a problem with these data |
| Target | Stromelysin-2 |
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| Ligand | BDBM50037061 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_205636 (CHEMBL813244) |
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| IC50 | 53000±n/a nM |
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| Citation |  Wright, SW; Petraitis, JJ; Abelman, MM; Batt, DG; Bostrom, LL; Corbett, RL; Decicco, CP; Di Meo, SV; Freimark, B; Giannaras, JV Heteroaryl-fused 2-phenylisothiazolone inhibitors of cartilage breakdown. J Med Chem37:3071-8 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Stromelysin-2 |
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| Name: | Stromelysin-2 |
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| Synonyms: | MMP10 | MMP10_HUMAN | Matrix Metalloproteinase-10 (MMP-10) | Matrix metalloproteinase 10 | STMY2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 54143.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P09238 |
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| Residue: | 476 |
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| Sequence: | MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV
KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY
TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL
AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN
SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST
LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW
AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG
FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
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| BDBM50037061 |
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| n/a |
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| Name | BDBM50037061 |
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| Synonyms: | 2-(2,5-Dimethoxy-phenyl)-isothiazolo[5,4-b]pyridin-3-one | CHEMBL104863 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H12N2O3S |
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| Mol. Mass. | 288.322 |
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| SMILES | COc1ccc(OC)c(c1)-n1sc2ncccc2c1=O |
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| Structure | 
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