Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
LigandBDBM350894
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1275747 (CHEMBL3091006)
IC50 6900±n/a nM
Citation Redondo, MSoteras, IBrea, JGonzález-García, ACadavid, MILoza, MIMartinez, AGil, CCampillo, NE Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities. Eur J Med Chem70:781-8 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Name:High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Synonyms:3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1)
Type:Enzyme
Mol. Mass.:55514.96
Organism:Homo sapiens (Human)
Description:Q13946
Residue:482
Sequence:
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM350894
n/a
NameBDBM350894
Synonyms:2-Ethylthio-3-phenyl-4-oxo-3,4-dihydroquinazoline | US9796687, Compound 16
TypeSmall organic molecule
Emp. Form.C16H14N2OS
Mol. Mass.282.36
SMILESCCSc1nc2ccccc2c(=O)n1-c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: