| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A1 |
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| Ligand | BDBM50494583 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1278709 (CHEMBL3096083) |
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| Ki | 228±n/a nM |
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| Citation |  Koch, P; Akkari, R; Brunschweiger, A; Borrmann, T; Schlenk, M; Küppers, P; Köse, M; Radjainia, H; Hockemeyer, J; Drabczy?ska, A; Kie?-Kononowicz, K; Müller, CE 1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases. Bioorg Med Chem21:7435-52 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A1 |
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| Name: | Adenosine receptor A1 |
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| Synonyms: | AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1 |
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| Type: | Protein |
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| Mol. Mass.: | 36704.13 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 326 |
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| Sequence: | MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVT
QRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFL
KIWNDHFRCQPKPPIDEDLPEEKAED
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| BDBM50494583 |
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| n/a |
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| Name | BDBM50494583 |
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| Synonyms: | CHEMBL3093332 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N5O4 |
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| Mol. Mass. | 395.4118 |
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| SMILES | COc1cc(OC)cc(c1)N1CCCn2c1nc1n(C)c(=O)n(CC#C)c(=O)c21 |
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| Structure | 
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