| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50041933 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_54130 |
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| IC50 | >10000±n/a nM |
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| Citation |  Rosowsky, A; Mota, CE; Wright, JE; Freisheim, JH; Heusner, JJ; McCormack, JJ; Queener, SF 2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. J Med Chem36:3103-12 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
|
|
|
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| BDBM50041933 |
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| n/a |
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| Name | BDBM50041933 |
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| Synonyms: | 5-Methyl-6-[2-(3,4,5-trimethoxy-phenyl)-ethyl]-thieno[2,3-d]pyrimidine-2,4-diamine | CHEMBL322861 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H22N4O3S |
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| Mol. Mass. | 374.457 |
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| SMILES | COc1cc(CCc2sc3nc(N)nc(N)c3c2C)cc(OC)c1OC |
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| Structure | 
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