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TargetAcyl-CoA:cholesterol acyltransferase
LigandBDBM50045906
Substrate/Competitorn/a
Meas. Tech.ChEBML_28349
IC50 6±n/a nM
Citation Augelli-Szafran, CEBlankley, CJRoth, BDTrivedi, BKBousley, RFEssenburg, ADHamelehle, KLKrause, BRStanfield, RL Inhibitors of acyl-CoA:cholesterol acyltransferase. 5. Identification and structure-activity relationships of novel beta-ketoamides as hypocholesterolemic agents. J Med Chem36:2943-9 (1993) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Acyl-CoA:cholesterol acyltransferase
Name:Acyl-CoA:cholesterol acyltransferase
Synonyms:ACAT
Type:n/a
Mol. Mass.:35405.31
Organism:Oryctolagus cuniculus
Description:n/a
Residue:305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIF
VARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLP
TVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYI
VLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLF
APTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVL
VLCIF
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  Blast E-value cutoff:
BDBM50045906
n/a
NameBDBM50045906
Synonyms:3-Oxo-hexadecanoic acid (2,6-diisopropyl-phenyl)-amide | CHEMBL102026
TypeSmall organic molecule
Emp. Form.C28H47NO2
Mol. Mass.429.6783
SMILESCCCCCCCCCCCCCC(=O)CC(=O)Nc1c(cccc1C(C)C)C(C)C
Structure
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