Reaction Details |
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Target | Histone deacetylase 1 |
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Ligand | BDBM19422 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1541050 (CHEMBL3744281) |
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IC50 | 18220±n/a nM |
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Citation | Zwick, V; Nurisso, A; Simões-Pires, C; Bouchet, S; Martinet, N; Lehotzky, A; Ovadi, J; Cuendet, M; Blanquart, C; Bertrand, P Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates. Bioorg Med Chem Lett26:154-9 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 1 |
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Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM19422 |
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n/a |
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Name | BDBM19422 |
Synonyms: | 4-(acetylamino)-N-(2-amino-phenyl) benzamide | CI-994 | N-(2-aminophenyl)-4-acetamidobenzamide | N-acetyldinaline | US11207431, Example F | US11377423, CI-994 |
Type | Small organic molecule |
Emp. Form. | C15H15N3O2 |
Mol. Mass. | 269.2985 |
SMILES | CC(=O)Nc1ccc(cc1)C(=O)Nc1ccccc1N |
Structure |
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