Reaction Details | |||
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Target | Sodium channel protein type 1 subunit alpha | ||
Ligand | BDBM217483 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1822227 (CHEMBL4321991) | ||
IC50 | >14000±n/a nM | ||
Citation | Mulcahy, JV; Pajouhesh, H; Beckley, JT; Delwig, A; Du Bois, J; Hunter, JC Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform Na J Med Chem62:8695-8710 (2019) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Sodium channel protein type 1 subunit alpha | |||
Name: | Sodium channel protein type 1 subunit alpha | ||
Synonyms: | NAC1 | SCN1 | SCN1A | SCN1A_HUMAN | Sodium (Site 1) | Sodium channel alpha subunit | Sodium channel protein type 1 subunit alpha | Sodium channel protein type I alpha subunit | Sodium channel protein type I subunit alpha | Sodium channel protein, brain I subunit alpha | Voltage-gated sodium channel subunit alpha Nav1.1 | ||
Type: | Protein | ||
Mol. Mass.: | 228952.47 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P35498 | ||
Residue: | 2009 | ||
Sequence: |
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BDBM217483 | |||
n/a | |||
Name | BDBM217483 | ||
Synonyms: | US9212182, 477 | US9212182, 478 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H16ClF2N3O5S | ||
Mol. Mass. | 543.926 | ||
SMILES | COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cc(F)cc(Cl)c1 |(-1.33,-5.39,;,-4.62,;1.33,-5.39,;1.33,-6.93,;2.67,-7.7,;4,-6.93,;5.33,-7.7,;4,-5.39,;2.67,-4.62,;2.67,-3.08,;1.33,-2.31,;,-3.08,;-1.33,-2.31,;-1.33,-.77,;;1.33,-.77,;2.67,,;4,-.77,;4,-2.31,;5.33,-3.08,;-2.67,,;-3.44,-1.33,;-1.9,1.33,;-4,.77,;-4,2.31,;-5.25,3.22,;-4.77,4.68,;-3.23,4.68,;-2.76,3.22,;2.67,-9.24,;1.33,-10.01,;1.33,-11.55,;,-12.32,;2.67,-12.32,;4,-11.55,;5.33,-12.32,;4,-10.01,)| | ||
Structure |