| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Arginase-1 |
|---|
| Ligand | BDBM50509011 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1837116 (CHEMBL4337249) |
|---|
| IC50 | 1.3±n/a nM |
|---|
| Citation |  Van Zandt, MC; Jagdmann, GE; Whitehouse, DL; Ji, M; Savoy, J; Potapova, O; Cousido-Siah, A; Mitschler, A; Howard, EI; Pyle, AM; Podjarny, AD Discovery of J Med Chem62:8164-8177 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Arginase-1 |
|---|
| Name: | Arginase-1 |
|---|
| Synonyms: | ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 34737.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_978893 |
|---|
| Residue: | 322 |
|---|
| Sequence: | MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
|
|
|
|---|
| BDBM50509011 |
|---|
| n/a |
|---|
| Name | BDBM50509011 |
|---|
| Synonyms: | CHEMBL4538713 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H28BN3O4 |
|---|
| Mol. Mass. | 349.233 |
|---|
| SMILES | N[C@H](CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O)Cc1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
