| Reaction Details |
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 | Report a problem with these data |
| Target | V-type proton ATPase subunit S1 |
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| Ligand | BDBM50064440 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_215472 (CHEMBL816941) |
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| IC50 | >10000±n/a nM |
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| Citation |  Gagliardi, S; Gatti, PA; Belfiore, P; Zocchetti, A; Clarke, GD; Farina, C Synthesis and structure-activity relationships of bafilomycin A1 derivatives as inhibitors of vacuolar H+-ATPase. J Med Chem41:1883-93 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| V-type proton ATPase subunit S1 |
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| Name: | V-type proton ATPase subunit S1 |
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| Synonyms: | ATP6AP1 | ATP6IP1 | ATP6S1 | Protein XAP-3 | V-ATPase Ac45 subunit | V-ATPase S1 accessory protein | V-ATPase subunit S1 | V-type proton ATPase subunit S1 | VAS1_HUMAN | VATPS1 | Vacuolar ATP synthase subunit S1 | Vacuolar proton pump subunit S1 | XAP3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52022.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_215469 |
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| Residue: | 470 |
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| Sequence: | MMAAMATARVRMGPRCAQALWRMPWLPVFLSLAAAAAAAAAEQQVPLVLWSSDRDLWAPA
ADTHEGHITSDLQLSTYLDPALELGPRNVLLFLQDKLSIEDFTAYGGVFGNKQDSAFSNL
ENALDLAPSSLVLPAVDWYAVSTLTTYLQEKLGASPLHVDLATLRELKLNASLPALLLIR
LPYTASSGLMAPREVLTGNDEVIGQVLSTLKSEDVPYTAALTAVRPSRVARDVAVVAGGL
GRQLLQKQPVSPVIHPPVSYNDTAPRILFWAQNFSVAYKDQWEDLTPLTFGVQELNLTGS
FWNDSFARLSLTYERLFGTTVTFKFILANRLYPVSARHWFTMERLEVHSNGSVAYFNASQ
VTGPSIYSFHCEYVSSLSKKGSLLVARTQPSPWQMMLQDFQIQAFNVMGEQFSYASDCAS
FFSPGIWMGLLTSLFMLFIFTYGLHMILSLKTMDRFDDHKGPTISLTQIV
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| BDBM50064440 |
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| n/a |
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| Name | BDBM50064440 |
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| Synonyms: | (2S,3R,4S)-4-((4E,6E,12E,14Z)-(2R,3S,9S,11R)-3,15-Dimethoxy-7,9,11,13-tetramethyl-10,16-dioxo-oxacyclohexadeca-4,6,12,14-tetraen-2-yl)-3-hydroxy-2-methyl-pentanoic acid methyl ester | CHEMBL291450 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H42O8 |
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| Mol. Mass. | 506.6283 |
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| SMILES | CO[C@H]1\C=C\C=C(C)\C[C@H](C)C(=O)[C@H](C)\C=C(/C)\C=C(OC)\C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)C(=O)OC |c:5,15,18,t:3| |
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| Structure | 
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