| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-2/subunit gamma-1 |
|---|
| Ligand | BDBM50246120 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1843854 (CHEMBL4344281) |
|---|
| EC50 | 40±n/a nM |
|---|
| Citation |  Romero, FA; Jones, CT; Xu, Y; Fenaux, M; Halcomb, RL The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease. J Med Chem63:5031-5073 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-2/subunit gamma-1 |
|---|
| Name: | 5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-2/subunit gamma-1 |
|---|
| Synonyms: | Prkaa1/Prkab2/Prkag1 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 1843854 |
|---|
| Components: | This complex has 3 components. |
|---|
| Component 1 |
| Name: | 5'-AMP-activated protein kinase catalytic subunit alpha-1 |
|---|
| Synonyms: | 5'-AMP-activated protein kinase catalytic subunit alpha-1/beta-1/gamma-1 | AAPK1_RAT | AMP-activated protein kinase, alpha-1 subunit | Ampk1 | Prkaa1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 63987.64 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_529575 |
|---|
| Residue: | 559 |
|---|
| Sequence: | MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR
QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG
RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF
LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG
IFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID
DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS
FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDI
MAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDE
ITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSEVSLTSSVTSLDSSPVDVAPRPG
SHTIEFFEMCANLIKILAQ
|
|
|
|---|
| Component 2 |
| Name: | 5'-AMP-activated protein kinase subunit gamma-1 |
|---|
| Synonyms: | 5'-AMP-activated protein kinase catalytic subunit alpha-1/beta-1/gamma-1 | AAKG1_RAT | AMPK gamma1 | AMPK subunit gamma-1 | AMPKg | Prkag1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 37388.74 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_117047 |
|---|
| Residue: | 330 |
|---|
| Sequence: | MESVAAESAPAPENEHSQETPESNSSVYTTFMKSHRCYDLIPTSSKLVVFDTSLQVKKAF
FALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVY
LQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFIT
EFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIY
SKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLEAIINRLVEAEVHRLV
VVDEHDVVKGIVSLSDILQALVLTGGEKKP
|
|
|
|---|
| Component 3 |
| Name: | 5'-AMP-activated protein kinase subunit beta-2 |
|---|
| Synonyms: | AAKB2_RAT | AMPK subunit beta-2 | Prkab2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 30226.28 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_119733 |
|---|
| Residue: | 271 |
|---|
| Sequence: | MGNTTSERVSGERHGAKAARAEGGGHGPGKEHKIMVGSTDDPSVFSLPDSKLPGDKEFVP
WQQDLDDSVKPTQQARPTVIRWSEGGKEVFISGSFNNWSTKIPLIKSHNDFVAILDLPEG
EHQYKFFVDGQWVHDPSEPVVTSQLGTINNLIHVKKSDFEVFDALKLDSMESSETSCRDL
SSSPPGPYGQEMYVFRSEERFKSPPILPPHLLQVILNKDTNISCDPALLPEPNHVMLNHL
YALSTKDSVMVLSATHRYKKKYVTTLLYKPI
|
|
|
|---|
| BDBM50246120 |
|---|
| n/a |
|---|
| Name | BDBM50246120 |
|---|
| Synonyms: | CHEMBL4082745 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H19ClN2O3 |
|---|
| Mol. Mass. | 454.904 |
|---|
| SMILES | Cc1ccc(Oc2nc3cc(c(Cl)cc3[nH]2)-c2ccc(cc2)-c2ccccc2)cc1C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
