| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 3 |
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| Ligand | BDBM50513283 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1852925 (CHEMBL4353549) |
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| Ki | >10000±n/a nM |
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| Citation |  Angeli, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Bartolucci, G; Menicatti, M; Carta, F; Supuran, CT Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects. Eur J Med Chem177:188-197 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 3 |
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| Name: | Carbonic anhydrase 3 |
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| Synonyms: | CA-III | CA3 | CAH3_HUMAN | Carbonate dehydratase III | Carbonic Anhydrase III | Carbonic anhydrase | Carbonic anhydrase 3 (CA III) | Carbonic anhydrase III (CA III) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29562.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human cloned isozyme. |
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| Residue: | 260 |
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| Sequence: | MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVSYDGGSAKTIL
NNGKTCRVVFDDTYDRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHL
VHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFLDALDKIKTKGKEAPFTKFDP
SCLFPACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPL
VSNWRPPQPINNRVVRASFK
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| BDBM50513283 |
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| n/a |
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| Name | BDBM50513283 |
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| Synonyms: | CHEMBL4534829 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H26N4O5S |
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| Mol. Mass. | 422.499 |
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| SMILES | CC1CCCC2(C1)NC(=O)N(CC(=O)NCCc1ccc(cc1)S(N)(=O)=O)C2=O |
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| Structure | 
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