| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 5A, mitochondrial |
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| Ligand | BDBM50513285 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1852927 (CHEMBL4353551) |
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| Ki | 6181±n/a nM |
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| Citation |  Angeli, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Bartolucci, G; Menicatti, M; Carta, F; Supuran, CT Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects. Eur J Med Chem177:188-197 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 5A, mitochondrial |
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| Name: | Carbonic anhydrase 5A, mitochondrial |
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| Synonyms: | CA-VA | CA5 | CA5A | CAH5A_HUMAN | Carbonate dehydratase VA | Carbonic Anhydrase VA | Carbonic anhydrase 5A (CA VA) | Carbonic anhydrase 5A, mitochondrial | Carbonic anhydrase 5A, mitochondrial precursor | Carbonic anhydrase V | Carbonic anhydrase VA (CA VA) |
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| Type: | Enzyme |
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| Mol. Mass.: | 34755.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human (cloned) isozyme |
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| Residue: | 305 |
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| Sequence: | MLGRNTWKTSAFSFLVEQMWAPLWSRSMRPGRWCSQRSCAWQTSNNTLHPLWTVPVSVPG
GTRQSPINIQWRDSVYDPQLKPLRVSYEAASCLYIWNTGYLFQVEFDDATEASGISGGPL
ENHYRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVI
GVFLKLGAHHQTLQRLVDILPEIKHKDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPPLT
ESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATN
EGTRS
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| BDBM50513285 |
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| n/a |
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| Name | BDBM50513285 |
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| Synonyms: | CHEMBL4553772 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H26N4O5S |
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| Mol. Mass. | 422.499 |
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| SMILES | NS(=O)(=O)c1ccc(CCNC(=O)CN2C(=O)NC3(CCCCCC3)C2=O)cc1 |
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| Structure | 
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