| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 12 |
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| Ligand | BDBM50341395 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1860796 (CHEMBL4361652) |
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| Ki | 2.8±n/a nM |
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| Citation |  Berrino, E; Milazzo, L; Micheli, L; Vullo, D; Angeli, A; Bozdag, M; Nocentini, A; Menicatti, M; Bartolucci, G; di Cesare Mannelli, L; Ghelardini, C; Supuran, CT; Carta, F Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis. J Med Chem62:7233-7249 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 12 |
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| Name: | Carbonic anhydrase 12 |
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| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39456.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Catalytic domain of human cloned isozyme was used in the assay |
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| Residue: | 354 |
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| Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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| BDBM50341395 |
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| n/a |
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| Name | BDBM50341395 |
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| Synonyms: | CHEMBL4175369 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H9NO2SSe |
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| Mol. Mass. | 274.2 |
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| SMILES | [#7]S(=O)(=O)c1ccc([Se;v2][#6]C#C)cc1 |
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| Structure | 
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