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TargetNeutrophil elastase
LigandBDBM50516762
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1866701 (CHEMBL4367676)
IC50 2700±n/a nM
Citation Fernandes, GFSDenny, WADos Santos, JL Boron in drug design: Recent advances in the development of new therapeutic agents. Eur J Med Chem179:791-804 (2019) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neutrophil elastase
Name:Neutrophil elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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  Blast E-value cutoff:
BDBM50516762
n/a
NameBDBM50516762
Synonyms:CHEMBL4474485
TypeSmall organic molecule
Emp. Form.C12H11BN2OS
Mol. Mass.242.105
SMILESOB1N(Cc2ccccc2)N=Cc2ccsc12 |c:11|
Structure
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