| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK2 |
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| Ligand | BDBM50519158 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1874060 (CHEMBL4375349) |
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| Kd | 272±n/a nM |
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| Citation |  Qi, B; Zhong, L; He, J; Zhang, H; Li, F; Wang, T; Zou, J; Lin, YX; Zhang, C; Guo, X; Li, R; Shi, J Discovery of Inhibitors of Aurora/PLK Targets as Anticancer Agents. J Med Chem62:7697-7707 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PLK2 |
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| Name: | Serine/threonine-protein kinase PLK2 |
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| Synonyms: | PLK2 | PLK2_HUMAN | Polo-Like Kinase 2 | SNK | Serine/threonine-protein kinase PLK2 | Serine/threonine-protein kinase SNK | Serum-inducible kinase |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 78259.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Full-length human PLK2 was expressed as GST-fusion protein using baculovirus expression system. GST-PLK2 was purified by using glutathione sepharose chromatography. |
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| Residue: | 685 |
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| Sequence: | MELLRTITYQPAASTKMCEQALGKGCGADSKKKRPPQPPEESQPPQSQAQVPPAAPHHHH
HHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAK
PHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEP
EVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTI
CGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMP
SSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPA
KNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEEL
QPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLR
GCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPD
KKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRL
YLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLTTL
LMSGCSSELKNRMEYALNMLLQRCN
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| BDBM50519158 |
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| n/a |
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| Name | BDBM50519158 |
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| Synonyms: | CHEMBL4445812 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H13Cl2N3O2S |
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| Mol. Mass. | 442.318 |
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| SMILES | Clc1ccc(cc1Cl)C(=O)Nc1ccc2cc(ccc2c1)C(=O)Nc1nccs1 |
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| Structure | 
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