| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Corticotropin-releasing factor receptor 1 |
|---|
| Ligand | BDBM50075920 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_51129 |
|---|
| Ki | >10000±n/a nM |
|---|
| Citation |  Luthin, DR; Rabinovich, AK; Bhumralkar, DR; Youngblood, KL; Bychowski, RA; Dhanoa, DS; May, JM Synthesis and biological activity of oxo-7H-benzo[e]perimidine-4-carboxylic acid derivatives as potent, nonpeptide corticotropin releasing factor (CRF) receptor antagonists. Bioorg Med Chem Lett9:765-70 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Corticotropin-releasing factor receptor 1 |
|---|
| Name: | Corticotropin-releasing factor receptor 1 |
|---|
| Synonyms: | CRF-R | CRF1 | CRFR1_RAT | CRH-R 1 | Corticotropin releasing factor receptor | Corticotropin releasing factor receptor 1 | Corticotropin-releasing Factor Receptor 1 | Corticotropin-releasing hormone receptor 1 | Crhr | Crhr1 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 47870.75 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Receptor binding assays were performed using rat cortex homogenate. |
|---|
| Residue: | 415 |
|---|
| Sequence: | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEV
HQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPF
PIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS
VFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
|
|
|
|---|
| BDBM50075920 |
|---|
| n/a |
|---|
| Name | BDBM50075920 |
|---|
| Synonyms: | 7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid ((1R,2R)-2-amino-cyclohexyl)-amide | CHEMBL352131 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H20N4O2 |
|---|
| Mol. Mass. | 372.4198 |
|---|
| SMILES | N[C@@H]1CCCC[C@H]1NC(=O)c1ccc2C(=O)c3ccccc3-c3ncnc1c23 |
|---|
| Structure | 
|
|---|
Search and Browse
