| Reaction Details |
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 | Report a problem with these data |
| Target | DNA gyrase subunit A |
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| Ligand | BDBM50521804 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1885325 (CHEMBL4386907) |
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| IC50 | 19±n/a nM |
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| Citation |  Narramore, S; Stevenson, CEM; Maxwell, A; Lawson, DM; Fishwick, CWG New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase. Bioorg Med Chem27:3546-3550 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA gyrase subunit A |
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| Name: | DNA gyrase subunit A |
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| Synonyms: | 5.6.2.2 | DNA gyrase subunit A | gyrA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 97006.20 |
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| Organism: | Escherichia coli |
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| Description: | ChEMBL_117105 |
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| Residue: | 875 |
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| Sequence: | MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWN
KAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAM
RYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMAT
NIPPHNLTEVINGCLAYIDDEDISIEGLMEHIPEPDFPTAAIINGRRGIEEAYRTGRGKV
YIRARAEVEVDAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDG
MRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRRE
VVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRHAPTPAEAKTALVANPWQLGNV
AAMLERAGDDAARPEWLEPEFGVRDGLYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
LLDQIAELLRILGSADRLMEVIREELELVREQFGDKRRTEITANSADINLEDLITQEDVV
VTLSHQGYVKYQPLSEYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDHILCFSSRGRVY
SMKVYQLPEATRGARGRPIVNLLPLEQDERITAILPVTEFEEGVKVFMATANGTVKKTVL
TEFNRLRTAGKVAIKLVDGDELIGVDLTSGEDEVMLFSAEGKVVRFKESSVRAMGCNTTG
VRGIRLGEGDKVVSLIVPRGDGAILTATQNGYGKRTAVAEYPTKSRATKGVISIKVTERN
GLVVGAVQVDDCDQIMMITDAGTLVRTRVSEISIVGRNTQGVILIRTAEDENVVGLQRVA
EPVDEEDLDTIDGSAAEGDDEIAPEVDVDDEPEEE
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| BDBM50521804 |
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| n/a |
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| Name | BDBM50521804 |
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| Synonyms: | CHEMBL4581035 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22N6O3 |
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| Mol. Mass. | 406.4378 |
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| SMILES | CCNC(=O)Nc1cc(Nc2ccc(OC)cc2)c(cn1)C(=O)Nc1cccnc1 |
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| Structure | 
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