| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 |
|---|
| Ligand | BDBM50525160 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1895831 (CHEMBL4397866) |
|---|
| Ki | >5000±n/a nM |
|---|
| Citation |  Khair, NZ; Lenjisa, JL; Tadesse, S; Kumarasiri, M; Basnet, SKC; Mekonnen, LB; Li, M; Diab, S; Sykes, MJ; Albrecht, H; Milne, R; Wang, S Discovery of CDK5 Inhibitors through Structure-Guided Approach. ACS Med Chem Lett10:786-791 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 |
|---|
| Name: | Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 |
|---|
| Synonyms: | CDK1/B | CDK1/Cyclin B | CDK1/CyclinB | Cyclin B/Dependent Kinase 1 (CDK1) | Cyclin-Dependent Kinase 1 (CDK1) | Cyclin-dependent kinase 1/cyclin B1 | Cyclin-dependent kinase/G2/mitotic-specific cyclin 1 | cdk1 |
|---|
| Type: | Protein Complex |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | CDK1/Cyclin B complexes were purified from insect cells co-infected with baculovirus vectors containing each of the components. |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Cyclin-dependent kinase 1 |
|---|
| Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 34101.08 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06493 |
|---|
| Residue: | 297 |
|---|
| Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
|
|
|
|---|
| Component 2 |
| Name: | G2/mitotic-specific cyclin-B1 |
|---|
| Synonyms: | CCNB | CCNB1 | CCNB1_HUMAN |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 48340.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P14635 |
|---|
| Residue: | 433 |
|---|
| Sequence: | MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKM
PMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPI
LVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQ
LEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVP
KKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRP
LPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGE
WTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNS
ALVQDLAKAVAKV
|
|
|
|---|
| BDBM50525160 |
|---|
| n/a |
|---|
| Name | BDBM50525160 |
|---|
| Synonyms: | CHEMBL4522230 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H17N3 |
|---|
| Mol. Mass. | 239.3156 |
|---|
| SMILES | Cc1ccccc1Nc1ncc2CCCCc2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
