| Reaction Details |
|---|
 | Report a problem with these data |
| Target | BDNF/NT-3 growth factors receptor |
|---|
| Ligand | BDBM50525709 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1897970 (CHEMBL4400005) |
|---|
| Kd | 1.7±n/a nM |
|---|
| Citation |  Subramanian, G; Bowen, SJ; Zhu, Y; Roush, N; Zachary, T; Javens, C; Williams, T; Janssen, A; Gonzales, A Type 2 inhibitor leads of human tropomyosin receptor kinase (hTrkA). Bioorg Med Chem Lett29:0 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| BDNF/NT-3 growth factors receptor |
|---|
| Name: | BDNF/NT-3 growth factors receptor |
|---|
| Synonyms: | GP145-TrkB | NTRK1/NTRK2 | NTRK2 | NTRK2_HUMAN | Neurotrophic tyrosine kinase receptor type 2 | TRKB | Trk-B | TrkB tyrosine kinase | Tropomyosin-related kinase B | Tropomyosin-related kinase B (TRKB) | Tyrosine kinase receptor B (Trk-B) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 91996.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16620 |
|---|
| Residue: | 822 |
|---|
| Sequence: | MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASP
LHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVL
KRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHI
VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQI
AAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWM
PPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQ
EVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
|
|
|
|---|
| BDBM50525709 |
|---|
| n/a |
|---|
| Name | BDBM50525709 |
|---|
| Synonyms: | CHEMBL4555143 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H23N7OS |
|---|
| Mol. Mass. | 433.529 |
|---|
| SMILES | CC(C)(C)c1cc(NC(=O)CSc2nnnn2-c2ccccc2)n(n1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
