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TargetKallikrein-1
LigandBDBM50525901
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1898424 (CHEMBL4400459)
IC50<10000±n/a nM
Citation Walker, ALDenis, ABingham, RPBouillot, AEdgar, EVFerrie, AHolmes, DSLaroze, ALiddle, JFouchet, MHMoquette, ANassau, PPearce, ACPolyakova, OSmith, KJThomas, PThorpe, JHTrottet, LWang, YHovnanian, A Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors. Bioorg Med Chem Lett29:0 (2019) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kallikrein-1
Name:Kallikrein-1
Synonyms:KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein
Type:Enzyme
Mol. Mass.:28874.69
Organism:Homo sapiens (Human)
Description:P06870
Residue:262
Sequence:
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
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  Blast E-value cutoff:
BDBM50525901
n/a
NameBDBM50525901
Synonyms:CHEMBL4448315
TypeSmall organic molecule
Emp. Form.C21H20BClFN3O3
Mol. Mass.427.664
SMILESCl.NC(=N)c1ccc(CC2OB(O)c3ccc(F)cc23)cc1OCc1cccnc1
Structure
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