| Reaction Details |
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 | Report a problem with these data |
| Target | Kallikrein-1 |
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| Ligand | BDBM50525901 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1898424 (CHEMBL4400459) |
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| IC50 | <10000±n/a nM |
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| Citation |  Walker, AL; Denis, A; Bingham, RP; Bouillot, A; Edgar, EV; Ferrie, A; Holmes, DS; Laroze, A; Liddle, J; Fouchet, MH; Moquette, A; Nassau, P; Pearce, AC; Polyakova, O; Smith, KJ; Thomas, P; Thorpe, JH; Trottet, L; Wang, Y; Hovnanian, A Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors. Bioorg Med Chem Lett29:0 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kallikrein-1 |
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| Name: | Kallikrein-1 |
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| Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
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| Type: | Enzyme |
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| Mol. Mass.: | 28874.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06870 |
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| Residue: | 262 |
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| Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
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| BDBM50525901 |
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| n/a |
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| Name | BDBM50525901 |
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| Synonyms: | CHEMBL4448315 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20BClFN3O3 |
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| Mol. Mass. | 427.664 |
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| SMILES | Cl.NC(=N)c1ccc(CC2OB(O)c3ccc(F)cc23)cc1OCc1cccnc1 |
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| Structure | 
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