| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-alpha |
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| Ligand | BDBM50082042 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_196757 (CHEMBL800546) |
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| EC50 | 84±n/a nM |
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| Citation |  Zacheis, D; Dhar, A; Lu, S; Madler, MM; Klucik, J; Brown, CW; Liu, S; Clement, F; Subramanian, S; Weerasekare, GM; Berlin, KD; Gold, MA; Houck, JR; Fountain, KR; Benbrook, DM Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors. J Med Chem42:4434-45 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor RXR-alpha |
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| Name: | Retinoic acid receptor RXR-alpha |
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| Synonyms: | Nr2b1 | RXRA_MOUSE | Retinoid X receptor alpha | Rxra |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51225.80 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_196493 |
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| Residue: | 467 |
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| Sequence: | MDTKHFLPLDFSTQVNSSSLNSPTGRGSMAVPSLHPSLGPGIGSPLGSPGQLHSPISTLS
SPINGMGPPFSVISSPMGPHSMSVPTTPTLGFGTGSPQLNSPMNPVSSTEDIKPPLGLNG
VLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNK
DCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVEKI
LEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLD
DQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVS
KMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRF
AKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQAT
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| BDBM50082042 |
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| n/a |
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| Name | BDBM50082042 |
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| Synonyms: | CHEMBL139536 | N-(2,2,4,4-Tetramethyl-thiochroman-6-yl)-terephthalamic acid methyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25NO3S |
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| Mol. Mass. | 383.504 |
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| SMILES | COC(=O)c1ccc(cc1)C(=O)Nc1ccc2SC(C)(C)CC(C)(C)c2c1 |
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| Structure | 
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