Reaction Details |
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Target | DNA repair protein RAD51 homolog 1 |
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Ligand | BDBM50527125 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1902246 (CHEMBL4404468) |
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EC50 | 19000±n/a nM |
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Citation | Bagnolini, G; Milano, D; Manerba, M; Schipani, F; Ortega, JA; Gioia, D; Falchi, F; Balboni, A; Farabegoli, F; De Franco, F; Robertson, J; Pellicciari, R; Pallavicini, I; Peri, S; Minucci, S; Girotto, S; Di Stefano, G; Roberti, M; Cavalli, A Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib. J Med Chem63:2588-2619 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA repair protein RAD51 homolog 1 |
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Name: | DNA repair protein RAD51 homolog 1 |
Synonyms: | RAD51 | RAD51A | RAD51_HUMAN | RECA |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 36960.74 |
Organism: | Homo sapiens (Human) |
Description: | gi_49168602 |
Residue: | 339 |
Sequence: | MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKEL
INIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETG
SITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGL
SGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSA
RQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRL
YLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
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BDBM50527125 |
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n/a |
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Name | BDBM50527125 |
Synonyms: | CHEMBL4444995 |
Type | Small organic molecule |
Emp. Form. | C27H21BrClN3O2 |
Mol. Mass. | 534.832 |
SMILES | CCC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O |c:5| |
Structure |
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