| Reaction Details |
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 | Report a problem with these data |
| Target | D(3) dopamine receptor |
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| Ligand | BDBM50016307 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1904302 (CHEMBL4406524) |
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| EC50 | 115±n/a nM |
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| Citation |  Moritz, AE; Free, RB; Weiner, WS; Akano, EO; Gandhi, D; Abramyan, A; Keck, TM; Ferrer, M; Hu, X; Southall, N; Steiner, J; Aubé, J; Shi, L; Frankowski, KJ; Sibley, DR Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D J Med Chem63:5526-5567 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(3) dopamine receptor |
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| Name: | D(3) dopamine receptor |
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| Synonyms: | DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3 |
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| Type: | n/a |
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| Mol. Mass.: | 44243.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 400 |
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| Sequence: | MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
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| BDBM50016307 |
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| n/a |
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| Name | BDBM50016307 |
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| Synonyms: | CHEMBL3262808 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N2O3 |
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| Mol. Mass. | 340.4162 |
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| SMILES | COc1ccc(cc1)C(=O)N1CCN(CCOc2ccccc2)CC1 |
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| Structure | 
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