| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 4 |
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| Ligand | BDBM50084607 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_45422 (CHEMBL658749) |
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| Ki | 25±n/a nM |
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| Citation |  Scozzafava, A; Briganti, F; Ilies, MA; Supuran, CT Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes. J Med Chem43:292-300 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 4 |
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| Name: | Carbonic anhydrase 4 |
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| Synonyms: | CA-IV | CA4 | CAH4_BOVIN | Carbonate dehydratase IV | Carbonic Anhydrase IV | Carbonic anhydrase | Carbonic anhydrase 4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 35152.74 |
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| Organism: | Bos taurus (bovine) |
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| Description: | Bovine isozyme, isolated from lung microsomes |
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| Residue: | 312 |
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| Sequence: | MRLLLALLVLAAAPPQARAASHWCYQIQVKPSNYTCLEPDEWEGSCQNNRQSPVNIVTAK
TQLDPNLGRFSFSGYNMKHQWVVQNNGHTVMVLLENKPSIAGGGLSTRYQATQLHLHWSR
AMDRGSEHSFDGERFAMEMHIVHEKEKGLSGNASQNQFAEDEIAVLAFMVEDGSKNVNFQ
PLVEALSDIPRPNMNTTMKEGVSLFDLLPEEESLRHYFRYLGSLTTPTCDEKVVWTVFQK
PIQLHRDQILAFSQKLFYDDQQKVNMTDNVRPVQSLGQRQVFRSGAPGLLLAQPLPTLLA
PVLACLTVGFLR
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| BDBM50084607 |
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| n/a |
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| Name | BDBM50084607 |
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| Synonyms: | 2,6-Diethyl-1-[(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenecarbamoyl)-methyl]-4-phenyl-pyridinium; perchlorate | CHEMBL439957 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N5O3S2 |
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| Mol. Mass. | 446.566 |
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| SMILES | CCc1cc(cc(CC)[n+]1CC(=O)N=c1sc(nn1C)S(N)(=O)=O)-c1ccccc1 |w:13.13| |
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| Structure | 
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