Reaction Details |
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Target | 5-hydroxytryptamine receptor 1A |
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Ligand | BDBM50533619 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1926089 (CHEMBL4429161) |
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Ki | 28±n/a nM |
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Citation | Kumar, V; Bonifazi, A; Ellenberger, MP; Keck, TM; Pommier, E; Rais, R; Slusher, BS; Gardner, E; You, ZB; Xi, ZX; Newman, AH Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment. J Med Chem59:7634-50 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1A |
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Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A |
Type: | n/a |
Mol. Mass.: | 46122.49 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 422 |
Sequence: | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ
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BDBM50533619 |
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n/a |
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Name | BDBM50533619 |
Synonyms: | CHEMBL4517102 |
Type | Small organic molecule |
Emp. Form. | C25H30ClN3O3 |
Mol. Mass. | 455.977 |
SMILES | CCc1cccc(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4o3)CC2)c1Cl |
Structure |
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