| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclic GMP-AMP synthase |
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| Ligand | BDBM50250108 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1930091 (CHEMBL4433342) |
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| Kd | 200±n/a nM |
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| Citation |  Mortenson, PN; Erlanson, DA; de Esch, IJP; Jahnke, W; Johnson, CN Fragment-to-Lead Medicinal Chemistry Publications in 2017. J Med Chem62:3857-3872 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclic GMP-AMP synthase |
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| Name: | Cyclic GMP-AMP synthase |
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| Synonyms: | 2.7.7.86 | C6orf150 | CGAS | CGAS_HUMAN | Cyclic GMP-AMP synthase | MB21D1 | Mab-21 domain-containing protein 1 | Synonyms=C6orf150 | cGAMP synthase | h-cGAS |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58845.55 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117333 |
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| Residue: | 522 |
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| Sequence: | MQPWHGKAMQRASEAGATAPKASARNARGAPMDPTESPAAPEAALPKAGKFGPARKSGSR
QKKSAPDTQERPPVRATGARAKKAPQRAQDTQPSDATSAPGAEGLEPPAAREPALSRAGS
CRQRGARCSTKPRPPPGPWDVPSPGLPVSAPILVRRDAAPGASKLRAVLEKLKLSRDDIS
TAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLE
EYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKR
KRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLV
PKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQL
KERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKL
ENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF
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| BDBM50250108 |
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| n/a |
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| Name | BDBM50250108 |
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| Synonyms: | CHEMBL4096573 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20N4O4 |
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| Mol. Mass. | 380.3972 |
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| SMILES | OC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1cnn2c(O)cc(nc12)-c1ccccc1 |r| |
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| Structure | 
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