Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50536186 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1933058 (CHEMBL4478710) |
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Ki | 2.7±n/a nM |
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Citation | Reeve, SM; Scocchera, E; Ferreira, JJ; G-Dayanandan, N; Keshipeddy, S; Wright, DL; Anderson, AC Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations. J Med Chem59:6493-500 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_STAAU | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase (DfrB) | Tetrahydrofolate dehydrogenase | folA |
Type: | Enzyme |
Mol. Mass.: | 18249.71 |
Organism: | Staphylococcus aureus |
Description: | n/a |
Residue: | 159 |
Sequence: | MTLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRN
VVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRG
DTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRKK
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BDBM50536186 |
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n/a |
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Name | BDBM50536186 |
Synonyms: | CHEMBL4483572 |
Type | Small organic molecule |
Emp. Form. | C22H23N5O |
Mol. Mass. | 373.4509 |
SMILES | CCc1nc(N)nc(N)c1C#C[C@H](C)c1cc(OC)cc(c1)-c1ccncc1 |r| |
Structure |
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