| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
|---|
| Ligand | BDBM50537083 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1935710 (CHEMBL4481469) |
|---|
| EC50 | 1300±n/a nM |
|---|
| Citation |  Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a ?M MC4R Partial Agonist. J Med Chem62:2738-2749 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Melanocortin receptor 4 |
|---|
| Name: | Melanocortin receptor 4 |
|---|
| Synonyms: | MC4-R | MC4R_MOUSE | Mc4r |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 36964.43 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_1498850 |
|---|
| Residue: | 332 |
|---|
| Sequence: | MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVS
GVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTN
MKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPL
IYALRSQELRKTFKEIICFYPLGGICELSSRY
|
|
|
|---|
| BDBM50537083 |
|---|
| n/a |
|---|
| Name | BDBM50537083 |
|---|
| Synonyms: | CHEMBL4550976 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H42IN9O6 |
|---|
| Mol. Mass. | 775.637 |
|---|
| SMILES | CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
