| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase isozyme L3 |
|---|
| Ligand | BDBM50538549 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1973153 (CHEMBL4605971) |
|---|
| IC50 | >80000±n/a nM |
|---|
| Citation |  Leger, PR; Hu, DX; Biannic, B; Bui, M; Han, X; Karbarz, E; Maung, J; Okano, A; Osipov, M; Shibuya, GM; Young, K; Higgs, C; Abraham, B; Bradford, D; Cho, C; Colas, C; Jacobson, S; Ohol, YM; Pookot, D; Rana, P; Sanchez, J; Shah, N; Sun, M; Wong, S; Brockstedt, DG; Kassner, PD; Schwarz, JB; Wustrow, DJ Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity. J Med Chem63:5398-5420 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ubiquitin carboxyl-terminal hydrolase isozyme L3 |
|---|
| Name: | Ubiquitin carboxyl-terminal hydrolase isozyme L3 |
|---|
| Synonyms: | UCHL3 | UCHL3_HUMAN | Ubiquitin C-terminal Hydrolase L3 (UCH-L3) | Ubiquitin thioesterase L3 |
|---|
| Type: | Hydrolase; protease |
|---|
| Mol. Mass.: | 26168.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human recombinant UCH-L3 was purchased from Boston Biochem, Inc.(Cambridge, MA). |
|---|
| Residue: | 230 |
|---|
| Sequence: | MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITE
KYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLK
KFLEESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHL
YELDGRKPFPINHGETSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA
|
|
|
|---|
| BDBM50538549 |
|---|
| n/a |
|---|
| Name | BDBM50538549 |
|---|
| Synonyms: | CHEMBL4641424 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H19ClN4O2 |
|---|
| Mol. Mass. | 358.822 |
|---|
| SMILES | Nc1cc(ccn1)-c1cc(Cl)cc2CC(Oc12)C(=O)N1CCNCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
