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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Nuclear receptor subfamily 1 group I member 2 | ||
| Ligand | BDBM50541318 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1984146 (CHEMBL4617552) | ||
| EC50 | >14000±n/a nM | ||
| Citation |  Myers, MC; Bilder, DM; Cavallaro, CL; Chao, HJ; Su, S; Burford, NT; Nayeem, A; Wang, T; Yan, M; Langish, RA; Dabros, M; Li, YX; Rose, AV; Behnia, K; Onorato, JM; Gargalovic, PS; Wexler, RR; Lawrence, RM Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Nuclear receptor subfamily 1 group I member 2 | |||
| Name: | Nuclear receptor subfamily 1 group I member 2 | ||
| Synonyms: | NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1 | ||
| Type: | Nuclear receptor | ||
| Mol. Mass.: | 49774.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75469 | ||
| Residue: | 434 | ||
| Sequence: |
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| BDBM50541318 | |||
| n/a | |||
| Name | BDBM50541318 | ||
| Synonyms: | CHEMBL4632688 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H20N2O3 | ||
| Mol. Mass. | 288.3416 | ||
| SMILES | CCCCc1nc(=O)cc(O)n1-c1c(C)cccc1OC |(56.29,-35.76,;57.62,-36.53,;58.95,-35.76,;60.29,-36.53,;61.62,-35.75,;61.62,-34.21,;62.96,-33.44,;62.96,-31.9,;64.29,-34.21,;64.29,-35.74,;65.63,-36.51,;62.96,-36.51,;62.96,-38.05,;64.29,-38.81,;65.62,-38.04,;64.3,-40.36,;62.96,-41.13,;61.63,-40.36,;61.63,-38.82,;60.29,-38.05,;58.96,-38.82,)| | ||
| Structure | 
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