Reaction Details |
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Target | Substance-P receptor |
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Ligand | BDBM50101418 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_205730 (CHEMBL809497) |
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IC50 | 3.79±n/a nM |
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Citation | Ashwood, VA; Field, MJ; Horwell, DC; Julien-Larose, C; Lewthwaite, RA; McCleary, S; Pritchard, MC; Raphy, J; Singh, L Utilization of an intramolecular hydrogen bond to increase the CNS penetration of an NK(1) receptor antagonist. J Med Chem44:2276-85 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Substance-P receptor |
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Name: | Substance-P receptor |
Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46254.43 |
Organism: | Homo sapiens (Human) |
Description: | P25103 |
Residue: | 407 |
Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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BDBM50101418 |
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n/a |
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Name | BDBM50101418 |
Synonyms: | CHEMBL72895 | [1-(1H-Indol-3-ylmethyl)-3-methyl-1-(1-phenyl-ethylcarbamoyl)-butyl]-carbamic acid benzofuran-2-ylmethyl ester |
Type | Small organic molecule |
Emp. Form. | C33H35N3O4 |
Mol. Mass. | 537.6487 |
SMILES | CC(C)C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 |
Structure |
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