| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
|---|
| Ligand | BDBM50545117 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1994373 (CHEMBL4628268) |
|---|
| IC50 | >100000±n/a nM |
|---|
| Citation |  Yukawa, T; Nakahata, T; Okamoto, R; Ishichi, Y; Miyamoto, Y; Nishimura, S; Oikawa, T; Kubo, K; Adachi, R; Satomi, Y; Nakakariya, M; Amano, N; Kamaura, M; Matsunaga, N Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor. Bioorg Med Chem28:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
|---|
| Name: | Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
|---|
| Synonyms: | MOB | Medulla oblongata-derived protein | Protein Mob | SGMS1 | SMS1 | SMS1_HUMAN | Sphingomyelin synthase 1 | TMEM23 | Transmembrane protein 23 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 48630.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_109868 |
|---|
| Residue: | 413 |
|---|
| Sequence: | MKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGQDLINLTQEDFKKPPLCRVSSDNGQRL
LDMIETLKMEHHLEAHKNGHANGHLNIGVDIPTPDGSFSIKIKPNGMPNGYRKEMIKIPM
PELERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRV
QWAFSICEINGMILVGLWLIQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGM
HFNCSPKLFGDWEAQLRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYS
PRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEAS
QMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLSRQVKYSRLVNDT
|
|
|
|---|
| BDBM50545117 |
|---|
| n/a |
|---|
| Name | BDBM50545117 |
|---|
| Synonyms: | CHEMBL4647686 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H22F6N2O3 |
|---|
| Mol. Mass. | 500.4335 |
|---|
| SMILES | CCCOc1c(C(=O)N(C)Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(=O)n(C)c2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
