Reaction Details |
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Target | C-C chemokine receptor type 4 |
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Ligand | BDBM50545769 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1996546 (CHEMBL4630441) |
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IC50 | 59±n/a nM |
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Citation | Robles, O; Jackson, JJ; Marshall, L; Talay, O; Chian, D; Cutler, G; Diokno, R; Hu, DX; Jacobson, S; Karbarz, E; Kassner, PD; Ketcham, JM; McKinnell, J; Meleza, C; Reilly, MK; Riegler, E; Shunatona, HP; Wadsworth, A; Younai, A; Brockstedt, DG; Wustrow, DJ; Zibinsky, M Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors. J Med Chem63:8584-8607 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-C chemokine receptor type 4 |
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Name: | C-C chemokine receptor type 4 |
Synonyms: | C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5 |
Type: | Enzyme |
Mol. Mass.: | 41406.41 |
Organism: | Homo sapiens (Human) |
Description: | P51679 |
Residue: | 360 |
Sequence: | MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV
VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG
FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT
ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA
VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN
PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
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BDBM50545769 |
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n/a |
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Name | BDBM50545769 |
Synonyms: | CHEMBL4645325 |
Type | Small organic molecule |
Emp. Form. | C28H37Cl2N7O |
Mol. Mass. | 558.546 |
SMILES | CC(C)C(=O)NCCN1CCC[C@@H](C1)C1CN(C1)c1cnc2c(C)nn([C@H](C)c3ccc(Cl)cc3Cl)c2n1 |r| |
Structure |
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