Reaction Details |
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Target | Interstitial collagenase |
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Ligand | BDBM50108149 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_106297 (CHEMBL714553) |
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IC50 | >50000±n/a nM |
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Citation | Wada, CK; Holms, JH; Curtin, ML; Dai, Y; Florjancic, AS; Garland, RB; Guo, Y; Heyman, HR; Stacey, JR; Steinman, DH; Albert, DH; Bouska, JJ; Elmore, IN; Goodfellow, CL; Marcotte, PA; Tapang, P; Morgan, DW; Michaelides, MR; Davidsen, SK Phenoxyphenyl sulfone N-formylhydroxylamines (retrohydroxamates) as potent, selective, orally bioavailable matrix metalloproteinase inhibitors. J Med Chem45:219-32 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Interstitial collagenase |
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Name: | Interstitial collagenase |
Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
Type: | Enzyme |
Mol. Mass.: | 54010.26 |
Organism: | Homo sapiens (Human) |
Description: | P03956 |
Residue: | 469 |
Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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BDBM50108149 |
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n/a |
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Name | BDBM50108149 |
Synonyms: | CHEMBL75189 | N-Hydroxy-N-{3-morpholin-4-yl-1-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonylmethyl]-propyl}-formamide |
Type | Small organic molecule |
Emp. Form. | C22H25F3N2O7S |
Mol. Mass. | 518.503 |
SMILES | ON(C=O)C(CCN1CCOCC1)CS(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1 |
Structure |
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