| Reaction Details |
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 | Report a problem with these data |
| Target | Tubulin beta-3 chain |
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| Ligand | BDBM50552403 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2034212 (CHEMBL4688370) |
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| IC50 | 2.6±n/a nM |
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| Citation |  Xiang, W; Quadery, TM; Hamel, E; Luckett-Chastain, LR; Ihnat, MA; Mooberry, SL; Gangjee, A The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity. Bioorg Med Chem29:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tubulin beta-3 chain |
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| Name: | Tubulin beta-3 chain |
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| Synonyms: | TBB3_HUMAN | TUBB3 | TUBB4 | Tubulin beta-3 chain | Tubulin beta-4 chain | Tubulin beta-III |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50412.49 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_116898 |
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| Residue: | 450 |
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| Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYV
PRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRG
LKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEMYEDDEEESEAQGPK
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| BDBM50552403 |
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| n/a |
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| Name | BDBM50552403 |
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| Synonyms: | CHEMBL4800264 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N3O |
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| Mol. Mass. | 319.4002 |
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| SMILES | COc1cccc2cc(ccc12)N(C)c1nc(C)nc2CCCc12 |
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| Structure | 
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