| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 2 |
|---|
| Ligand | BDBM50556785 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2057270 (CHEMBL4712271) |
|---|
| Kd | 2000±n/a nM |
|---|
| Citation |  Hu, J; Wei, J; Yim, H; Wang, L; Xie, L; Jin, MS; Kabir, M; Qin, L; Chen, X; Liu, J; Jin, J Potent and Selective Mitogen-Activated Protein Kinase Kinase 1/2 (MEK1/2) Heterobifunctional Small-molecule Degraders. J Med Chem63:15883-15905 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity mitogen-activated protein kinase kinase 2 |
|---|
| Name: | Dual specificity mitogen-activated protein kinase kinase 2 |
|---|
| Synonyms: | Dual specificity mitogen-activated protein kinase kinase 2 (MEK2) | Dual specificity mitogen-activated protein kinase kinase; MEK1/2 | ERK activator kinase 2 | MAP kinase kinase 2 | MAP2K2 | MAPK/ERK kinase 2 | MAPKK 2 | MEK2 | MKK2 | MP2K2_HUMAN | PRKMK2 | VHL-MAP2K1/MAP2K2 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 44423.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_13489054 |
|---|
| Residue: | 400 |
|---|
| Sequence: | MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ
GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP
PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL
KMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
|
|
|
|---|
| BDBM50556785 |
|---|
| n/a |
|---|
| Name | BDBM50556785 |
|---|
| Synonyms: | CHEMBL4787502 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C52H69F3IN7O6S |
|---|
| Mol. Mass. | 1104.112 |
|---|
| SMILES | C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CCCCCCCCCCCNCCCCONC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F)C(C)(C)C)c1ccc(cc1)-c1scnc1C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
