| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ubiquitin-like modifier-activating enzyme ATG7 |
|---|
| Ligand | BDBM475984 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2074574 (CHEMBL4730108) |
|---|
| IC50 | 14±n/a nM |
|---|
| Citation |  Huang, SC; Adhikari, S; Brownell, JE; Calderwood, EF; Chouitar, J; D'Amore, NR; England, DB; Foley, K; Harrison, SJ; LeRoy, PJ; Lok, D; Lublinsky, A; Ma, LT; Menon, S; Yang, Y; Zhang, J; Gould, AE Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors. Bioorg Med Chem28:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ubiquitin-like modifier-activating enzyme ATG7 |
|---|
| Name: | Ubiquitin-like modifier-activating enzyme ATG7 |
|---|
| Synonyms: | APG7-like | APG7L | ATG12-activating enzyme E1 ATG7 | ATG7 | ATG7_HUMAN | Autophagy-related protein 7 | Ubiquitin-activating enzyme E1-like protein | hAGP7 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 77955.74 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_939703 |
|---|
| Residue: | 703 |
|---|
| Sequence: | MAAATGDPGLSKLQFAPFSSALDVGFWHELTQKKLNEYRLDEAPKDIKGYYYNGDSAGLP
ARLTLEFSAFDMSAPTPARCCPAIGTLYNTNTLESFKTADKKLLLEQAANEIWESIKSGT
ALENPVLLNKFLLLTFADLKKYHFYYWFCYPALCLPESLPLIQGPVGLDQRFSLKQIEAL
ECAYDNLCQTEGVTALPYFLIKYDENMVLVSLLKHYSDFFQGQRTKITIGVYDPCNLAQY
PGWPLRNFLVLAAHRWSSSFQSVEVVCFRDRTMQGARDVAHSIIFEVKLPEMAFSPDCPK
AVGWEKNQKGGMGPRMVNLSECMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLL
LGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAADR
LQKIFPGVNARGFNMSIPMPGHPVNFSSVTLEQARRDVEQLEQLIESHDVVFLLMDTRES
RWLPAVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPNHPVASADLLGSSLF
ANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQCTVSRPGLAVIAGALAVELMVSVLQHPEG
GYAIASSSDDRMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDKCTACSSKVLDQYERE
GFNFLAKVFNSSHSFLEDLTGLTLLHQETQAAEIWDMSDDETI
|
|
|
|---|
| BDBM475984 |
|---|
| n/a |
|---|
| Name | BDBM475984 |
|---|
| Synonyms: | US10865208, Compound I-42 | {(2R,3S,4R,5R)-5-[4-amino-3-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1- yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H16N6O6S2 |
|---|
| Mol. Mass. | 392.411 |
|---|
| SMILES | CSc1nn([C@@H]2O[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]2O)c2ncnc(N)c12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
