Reaction Details |
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Target | Ubiquitin-like modifier-activating enzyme ATG7 |
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Ligand | BDBM476086 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2074574 (CHEMBL4730108) |
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IC50 | 35±n/a nM |
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Citation | Huang, SC; Adhikari, S; Brownell, JE; Calderwood, EF; Chouitar, J; D'Amore, NR; England, DB; Foley, K; Harrison, SJ; LeRoy, PJ; Lok, D; Lublinsky, A; Ma, LT; Menon, S; Yang, Y; Zhang, J; Gould, AE Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors. Bioorg Med Chem28:0 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Ubiquitin-like modifier-activating enzyme ATG7 |
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Name: | Ubiquitin-like modifier-activating enzyme ATG7 |
Synonyms: | APG7-like | APG7L | ATG12-activating enzyme E1 ATG7 | ATG7 | ATG7_HUMAN | Autophagy-related protein 7 | Ubiquitin-activating enzyme E1-like protein | hAGP7 |
Type: | PROTEIN |
Mol. Mass.: | 77955.74 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_939703 |
Residue: | 703 |
Sequence: | MAAATGDPGLSKLQFAPFSSALDVGFWHELTQKKLNEYRLDEAPKDIKGYYYNGDSAGLP
ARLTLEFSAFDMSAPTPARCCPAIGTLYNTNTLESFKTADKKLLLEQAANEIWESIKSGT
ALENPVLLNKFLLLTFADLKKYHFYYWFCYPALCLPESLPLIQGPVGLDQRFSLKQIEAL
ECAYDNLCQTEGVTALPYFLIKYDENMVLVSLLKHYSDFFQGQRTKITIGVYDPCNLAQY
PGWPLRNFLVLAAHRWSSSFQSVEVVCFRDRTMQGARDVAHSIIFEVKLPEMAFSPDCPK
AVGWEKNQKGGMGPRMVNLSECMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLL
LGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAADR
LQKIFPGVNARGFNMSIPMPGHPVNFSSVTLEQARRDVEQLEQLIESHDVVFLLMDTRES
RWLPAVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPNHPVASADLLGSSLF
ANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQCTVSRPGLAVIAGALAVELMVSVLQHPEG
GYAIASSSDDRMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDKCTACSSKVLDQYERE
GFNFLAKVFNSSHSFLEDLTGLTLLHQETQAAEIWDMSDDETI
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BDBM476086 |
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n/a |
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Name | BDBM476086 |
Synonyms: | US10865208, Compound I-141 | [(2R,3R,4S,5R)-5-{4-amino-3-[(3-methylphenyl)sulfanyl]-1H-pyrazolo[3,4- d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate |
Type | Small organic molecule |
Emp. Form. | C17H19FN6O5S2 |
Mol. Mass. | 470.498 |
SMILES | Cc1cccc(Sc2nn([C@@H]3O[C@H](COS(N)(=O)=O)[C@@H](O)[C@@H]3F)c3ncnc(N)c23)c1 |r| |
Structure |
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