| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Solute carrier family 22 member 12 |
|---|
| Ligand | BDBM50561686 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2075742 (CHEMBL4731276) |
|---|
| IC50 | >100000±n/a nM |
|---|
| Citation |  Uda, J; Kobashi, S; Miyata, S; Ashizawa, N; Matsumoto, K; Iwanaga, T Discovery of Dotinurad (FYU-981), a New Phenol Derivative with Highly Potent Uric Acid Lowering Activity. ACS Med Chem Lett11:2017-2023 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Solute carrier family 22 member 12 |
|---|
| Name: | Solute carrier family 22 member 12 |
|---|
| Synonyms: | OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 59638.65 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96S37 |
|---|
| Residue: | 553 |
|---|
| Sequence: | MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
GTLGNSVLKSTQF
|
|
|
|---|
| BDBM50561686 |
|---|
| n/a |
|---|
| Name | BDBM50561686 |
|---|
| Synonyms: | CHEMBL4756625 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H9F3N2O4S |
|---|
| Mol. Mass. | 382.314 |
|---|
| SMILES | Oc1c(cc(cc1C(F)(F)F)C(=O)N1CS(=O)(=O)c2ccccc12)C#N |
|---|
| Structure | 
|
|---|
Search and Browse
