Reaction Details |
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Target | Tyrosine-protein kinase SYK |
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Ligand | BDBM50126446 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_201611 |
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IC50 | 1500±n/a nM |
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Citation | Cywin, CL; Zhao, BP; McNeil, DW; Hrapchak, M; Prokopowicz, AS; Goldberg, DR; Morwick, TM; Gao, A; Jakes, S; Kashem, M; Magolda, RL; Soll, RM; Player, MR; Bobko, MA; Rinker, J; DesJarlais, RL; Winters, MP Discovery and SAR of novel Naphthyridines as potent inhibitors of spleen tyrosine kinase (SYK). Bioorg Med Chem Lett13:1415-8 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase SYK |
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Name: | Tyrosine-protein kinase SYK |
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
Type: | Enzyme |
Mol. Mass.: | 72079.99 |
Organism: | Homo sapiens (Human) |
Description: | P43405 |
Residue: | 635 |
Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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BDBM50126446 |
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n/a |
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Name | BDBM50126446 |
Synonyms: | CHEMBL31668 | N*1*-[7-(4-Methoxy-phenyl)-[1,6]naphthyridin-5-yl]-ethane-1,2-diamine |
Type | Small organic molecule |
Emp. Form. | C17H18N4O |
Mol. Mass. | 294.351 |
SMILES | COc1ccc(cc1)-c1cc2ncccc2c(NCCN)n1 |
Structure |
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