| Reaction Details |
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 | Report a problem with these data |
| Target | Chloroquine resistance transporter |
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| Ligand | BDBM50563440 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2082532 (CHEMBL4738323) |
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| IC50 | 55000±n/a nM |
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| Citation |  Relitti, N; Federico, S; Pozzetti, L; Butini, S; Lamponi, S; Taramelli, D; D'Alessandro, S; Martin, RE; Shafik, SH; Summers, RL; Babij, SK; Habluetzel, A; Tapanelli, S; Caldelari, R; Gemma, S; Campiani, G Synthesis and biological evaluation of benzhydryl-based antiplasmodial agents possessing Plasmodium falciparum chloroquine resistance transporter (PfCRT) inhibitory activity. Eur J Med Chem215:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Chloroquine resistance transporter |
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| Name: | Chloroquine resistance transporter |
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| Synonyms: | CRT | CRT_PLAFA | PfCRT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48687.29 |
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| Organism: | Plasmodium falciparum |
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| Description: | ChEMBL_1364181 |
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| Residue: | 424 |
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| Sequence: | MKFASKKNNQKNSSKNDERYRELDNLVQEGNGSRLGGGSCLGKCAHVFKLIFKEIKDNIF
IYILSIIYLSVCVMNKIFAKRTLNKIGNYSFVTSETHNFICMIMFFIVYSLFGNKKGNSK
ERHRSFNLQFFAISMLDACSVILAFIGLTRTTGNIQSFVLQLSIPINMFFCFLILRYRYH
LYNYLGAVIIVVTIALVEMKLSFETQEENSIIFNLVLISALIPVCFSNMTREIVFKKYKI
DILRLNAMVSFFQLFTSCLILPVYTLPFLKQLHLPYNEIWTNIKNGFACLFLGRNTVVEN
CGLGMAKLCDDCDGAWKTFALFSFFNICDNLITSYIIDKFSTMTYTIVSCIQGPAIAIAY
YFKFLAGDVVREPRLLDFVTLFGYLFGSIIYRVGNIILERKKMRNEENEDSEGELTNVDS
IITQ
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| BDBM50563440 |
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| n/a |
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| Name | BDBM50563440 |
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| Synonyms: | CHEMBL4784051 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H28ClN3O |
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| Mol. Mass. | 457.994 |
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| SMILES | COc1cc(NC(c2ccc(CN3CCCC3)cc2)c2cccc(Cl)c2)c2ncccc2c1 |
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| Structure | 
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