| Reaction Details |
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 | Report a problem with these data |
| Target | TGF-beta receptor type-1 |
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| Ligand | BDBM50563626 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2083392 (CHEMBL4739183) |
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| IC50 | 9.0±n/a nM |
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| Citation |  Liu, YY; Guo, Z; Wang, JY; Wang, HM; Da Qi, J; Ma, J; Piao, HR; Jin, CH; Jin, X Synthesis and evaluation of the epithelial-to- mesenchymal inhibitory activity of indazole-derived imidazoles as dual ALK5/p38? MAP inhibitors. Eur J Med Chem216:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| TGF-beta receptor type-1 |
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| Name: | TGF-beta receptor type-1 |
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| Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I |
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| Type: | enzyme |
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| Mol. Mass.: | 55968.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P36897 |
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| Residue: | 503 |
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| Sequence: | MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
ARLTALRIKKTLSQLSQQEGIKM
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| BDBM50563626 |
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| n/a |
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| Name | BDBM50563626 |
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| Synonyms: | CHEMBL4798879 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22N6 |
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| Mol. Mass. | 394.4717 |
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| SMILES | Cc1ccc(NCc2nc(c([nH]2)-c2cccc(C)n2)-c2ccc3[nH]ncc3c2)cc1 |
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| Structure | 
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