Reaction Details |
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Target | Proprotein convertase subtilisin/kexin type 9 |
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Ligand | BDBM50565592 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2092914 (CHEMBL4774177) |
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EC50 | 11±n/a nM |
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Citation | Xie, H; Yang, K; Winston-McPherson, GN; Stapleton, DS; Keller, MP; Attie, AD; Smith, KA; Tang, W From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators. Eur J Med Chem206:0 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Proprotein convertase subtilisin/kexin type 9 |
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Name: | Proprotein convertase subtilisin/kexin type 9 |
Synonyms: | NARC-1 | NARC1 | Neural apoptosis-regulated convertase 1 | PC9 | PCSK9 | PCSK9_HUMAN | Proprotein convertase 9 | Proprotein convertase subtilisin/kexin type 9 | Proprotein convertase subtilisin/kexin type 9 (PCSK9) | Subtilisin/kexin type 9 | Subtilisin/kexin-like protease PC9 |
Type: | Enzyme |
Mol. Mass.: | 74286.93 |
Organism: | Homo sapiens (Human) |
Description: | Q8NBP7 |
Residue: | 692 |
Sequence: | MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGT
TATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLP
GFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLV
EVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAG
VAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAA
CQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVD
LFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSA
KDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPD
EELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAP
PAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASC
CHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRD
VSTTGSTSEGAVTAVAICCRSRHLAQASQELQ
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BDBM50565592 |
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n/a |
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Name | BDBM50565592 |
Synonyms: | CHEMBL4788701 |
Type | Small organic molecule |
Emp. Form. | C23H22F2N4O2 |
Mol. Mass. | 424.4432 |
SMILES | Cn1c(nc2ccc(F)cc12)C(=O)c1cn(CCN2CCOCC2)c2c(F)cccc12 |
Structure |
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