| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
|---|
| Ligand | BDBM50566438 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2100454 (CHEMBL4808850) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Abdel-Halim, M; Sigler, S; Racheed, NAS; Hefnawy, A; Fathalla, RK; Hammam, MA; Maher, A; Maxuitenko, Y; Keeton, AB; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity. J Med Chem64:4462-4477 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
|---|
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
|---|
| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 83318.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q07343 |
|---|
| Residue: | 736 |
|---|
| Sequence: | MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
ETDIDIATEDKSPVDT
|
|
|
|---|
| BDBM50566438 |
|---|
| n/a |
|---|
| Name | BDBM50566438 |
|---|
| Synonyms: | CHEMBL4852714 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H32N4O2 |
|---|
| Mol. Mass. | 468.59 |
|---|
| SMILES | COc1ccc(cc1)C1CC(=NN1c1ccc(cc1)C(=O)N1CCN(C)CC1)c1ccccc1C |c:11| |
|---|
| Structure | 
|
|---|
Search and Browse
