Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM50567163

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2102445 (CHEMBL4810841)

EC50

0.040000±n/a nM

Citation

Tora, G; Jiang, J; Bostwick, JS; Gargalovic, PS; Onorato, JM; Luk, CE; Generaux, C; Xu, C; Galella, MA; Wang, T; He, Y; Wexler, RR; Finlay, HJ Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists. Bioorg Med Chem Lett50:0 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM50567163

n/a

Name

BDBM50567163

Synonyms:

CHEMBL4863554

Type

Small organic molecule

Emp. Form.

C29H30N2O6S

Mol. Mass.

534.623

SMILES

CCCCc1[nH]c(=O)c(c(O)c1-c1c(OC)cccc1OC)S(=O)(=O)c1ccc(cc1)-c1ccncc1C |(53.9,-35.82,;55.23,-36.59,;56.57,-35.82,;57.9,-36.59,;59.23,-35.82,;59.24,-34.28,;60.57,-33.51,;60.56,-31.97,;61.9,-34.27,;61.91,-35.82,;63.24,-36.59,;60.57,-36.59,;60.57,-38.13,;61.9,-38.89,;63.23,-38.12,;64.57,-38.89,;61.91,-40.43,;60.57,-41.21,;59.23,-40.44,;59.23,-38.9,;57.9,-38.13,;56.57,-38.89,;63.23,-33.49,;62.45,-32.16,;64,-32.15,;64.57,-34.26,;64.57,-35.8,;65.9,-36.56,;67.24,-35.79,;67.22,-34.24,;65.89,-33.48,;68.57,-36.55,;69.89,-35.77,;71.23,-36.53,;71.24,-38.08,;69.91,-38.86,;68.58,-38.09,;67.24,-38.87,)|

Structure