Reaction Details |
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Target | Retinoic acid receptor RXR-alpha |
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Ligand | BDBM50133115 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_196896 (CHEMBL806515) |
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IC50 | 50±n/a nM |
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Citation | Michellys, PY; Ardecky, RJ; Chen, JH; D'Arrigo, J; Grese, TA; Karanewsky, DS; Leibowitz, MD; Liu, S; Mais, DA; Mapes, CM; Montrose-Rafizadeh, C; Ogilvie, KM; Reifel-Miller, A; Rungta, D; Thompson, AW; Tyhonas, JS; Boehm, MF Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. J Med Chem46:4087-103 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Retinoic acid receptor RXR-alpha |
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Name: | Retinoic acid receptor RXR-alpha |
Synonyms: | NR2B Channel Blocker | Nr2b1 | RXRA_RAT | Retinoic acid receptor RXR-alpha | Retinoid X receptor alpha | Rxra |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 51273.78 |
Organism: | RAT |
Description: | NR2B Channel Blocker 0 RAT::Q05343 |
Residue: | 467 |
Sequence: | MDTKHFLPLDFSTQVNSSSLSSPTGRGSMAAPSLHPSLGPGLGSPLGSPGQLHSPISTLS
SPINGMGPPFSVISSPMGPHSMSVPTTPTLGFETGSPQLNSPMNPVSSSEDIKPPLGLNG
VLKVPAHPSGNMSSFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNK
DCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVEKI
LEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLD
DQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVS
KMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRF
AKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQTT
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BDBM50133115 |
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n/a |
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Name | BDBM50133115 |
Synonyms: | 5-[2'-(3-Fluoro-propoxy)-3',5'-diisopropyl-biphenyl-2-yl]-3-methyl-penta-2,4-dienoic acid | CHEMBL445634 |
Type | Small organic molecule |
Emp. Form. | C27H33FO3 |
Mol. Mass. | 424.5475 |
SMILES | CC(C)c1cc(C(C)C)c(OCCCF)c(c1)-c1ccccc1\C=C\C(\C)=C\C(O)=O |
Structure |
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