| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK1 |
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| Ligand | BDBM50568981 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2107256 (CHEMBL4815931) |
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| IC50 | 14±n/a nM |
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| Citation |  Zhang, Y; Xia, A; Zhang, S; Lin, G; Liu, J; Chen, P; Mu, B; Jiao, Y; Xu, W; Chen, M; Li, L Discovery of 3,6-disubstutited-imidazo[1,2-a]pyridine derivatives as a new class of CLK1 inhibitors. Bioorg Med Chem Lett41:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase CLK1 |
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| Name: | Dual specificity protein kinase CLK1 |
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| Synonyms: | CDC-like kinase 1 | CDC-like kinase 1 (CLK1) | CDC2-like kinase 1 (CLK1) | CLK | CLK1 | CLK1_HUMAN | Dual specificity protein kinase CLK1 | Dual specificity protein kinase CLK1/CLK4 | Dual specificty protein kinase CLK1 |
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| Type: | Protein |
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| Mol. Mass.: | 57322.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49759 |
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| Residue: | 484 |
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| Sequence: | MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR
SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH
HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID
HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV
FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD
YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC
DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD
EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL
KKSI
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| BDBM50568981 |
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| n/a |
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| Name | BDBM50568981 |
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| Synonyms: | CHEMBL4877125 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19N5O |
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| Mol. Mass. | 345.3978 |
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| SMILES | C[C@@H](NC(=O)c1cnc2ccc(cn12)-c1cnn(C)c1)c1ccccc1 |r| |
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| Structure | 
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